Jenna Diefenderfer, Heather D. Bean, Emily A. Higgins Keppler. (2024) New Breath Diagnostics for Fungal Disease. Current Clinical Microbiology Reports, in press. Link


Carrie L. Jenkins, Heather D. Bean. (2023) Current limitations of staph infection diagnostics, and the role for VOCs in achieving culture-independent detection. Pathogens, 12, 181. Link

Emily A. Higgins Keppler, Marley C. Caballero Van Dyke, Heather L. Mead, Douglas F. Lake, D. Mitchell Magee, Bridget M. Marker, Heather D. Bean. (2023) Volatile Metabolites in Lavage Fluid Are Correlated with Cytokine Production in a Valley Fever Murine Model. Journal of Fungi, 9, 115. Editor's Choice Article Link


Trenton J. Davis*, Tarek Firzli*, Emily A. Higgins Keppler*, Matthew Richardson, Heather D. Bean. (2022) Addressing missing data in GC×GC metabolomics: Identifying missingness type and evaluating the impact of imputation methods on experimental replication. [*co-first authors] Analytical Chemistry, 94, 10912-10920. Published: Link Preprint: Link

Jennifer Barrila, Jiseon Yang, Karla P. Franco Meléndez, Shanshan Yang, Trenton J. Davis, Bruce J. Aronow, Heather D. Bean, Richard R. Davis, Rebecca J. Forsyth, C. Mark Ott, Sandhya Gangaraju, Bianca Y. Kang, Brian Hanratty, Seth D. Nydam, Eric A. Nauman, Wei Kong, Jason Steel, Cheryl A. Nickerson. (2022) Spaceflight analogue culture enhances the host-pathogen interaction between Salmonella and a 3-D biomimetic intestinal co-culture model. Frontiers in Cellular and Infection Microbiology, 12, 705647. Link


Emily A. Higgins Keppler, Heather L. Mead, Bridget M. Barker, Heather D. Bean. (2021) Life cycle dominates the volatilome character of dimorphic fungus Coccidioides spp. mSphere. 6e00040-21Link

(editorial) Heather D. Bean (2021). Hot Topics in Gas Chromatography: Using the three Cs of data visualization as a life raft when you’re drowning in multidimensional chromatography peaks. LCGC North America 39 (s6b), 16-18. Link


Trenton J. Davis, Ava V. Karanjia, Charity N. Bhebhe, Sarah B. West, Matthew Richardson, Heather D. Bean. (2020) Pseudomonas aeruginosa volatilome characteristics and adaptations in chronic cystic fibrosis lung infections. mSphere. 5, e00843-20. Link

Carrie L. Jenkins, Heather D. Bean. (2020) Dependence of the staphylococcal volatile metabolome composition on microbial nutrition. Metabolites. 10, 347. Link

Cristina E. DavisJane E. Hill, Matthias Frank, Mitchell M. McCartney, Michael Schivo, Heather D. Bean. Breath analysis for respiratory infections, in Breathborne Biomarkers and the Human Volatilome, C. E. Davis, J. D. Beauchamp, J. D. Pleil, Eds. Elsevier: Amsterdam, Netherlands, 2020; pp. 335-347.

Jarrett Eshima, Trenton J. Davis, Heather D. Bean, John Fricks, Barbara S. Smith. (2020) A metabolomic approach for predicting circadian changes in cortisol. Metabolites. 10, 194. Link

Ghazal Ebadzadsahrai, Emily A. Higgins Keppler, Scott Soby, Heather D. Bean. (2020) Inhibition of fungal growth and induction of a novel volatilome in response to Chromobacterium vaccinii volatile organic compounds. Frontiers in Microbiology. 11, 1035. Link

Heather L. Mead, Chandler C. Roe, Emily A. Higgins Keppler, Marley C. Caballero Van Dyke, Klaire L. Laux, Aubrey L., Funke, Karis J. Miller, Heather D. Bean, Jason W. Sahl, Bridget M. Barker. (2020) Defining critical genes during spherule remodeling and endospore development in the fungal pathogen Coccidioides posadasii. Frontiers in Genetics. 11, 483. Link

Andrea Hahn, Katrine L. Whiteson, Trenton J. Davis, Joann Phan, Iman Sami, Anastassios C. Koumbourlis, Robert J. Freishtat, Keith A. Crandall, Heather D. Bean. (2020) Longitudinal associations of the cystic fibrosis airway microbiome and volatile metabolites: A case study. Frontiers in Cellular and Infection Microbiology. 10, 174Link

Carrie L. Jenkins, Heather D. Bean. (2020) Influence of media on the differentiation of Staphylococcus spp. by volatile compounds. Journal of Breath Research. 14, 016007. Link


(editorial) Heather D. Bean (2019). In my view: Repeat after me… How committed are we to reproducibility in science? The Analytical Scientist 82. Link

Jarrett Eshima, Stephanie Ong, Trenton J. Davis, Christopher Miranda, Devika Krishnamurthay, Abigael Nachtsheim, Christopher Plaiser, John Stufken, John Fricks, Heather D. Bean, Barbara S. Smith. (2019) Monitoring changes in the healthy female metabolome across the menstrual cycle using GC×GC-TOFMS. Journal of Chromatography B. 1121, 48-57. Link


Emily A. Higgins Keppler, Carrie L. Jenkins, Trenton J. Davis, Heather D. Bean (2018). Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics. Trends in Analytical Chemistry 109, 275-286. Link

Mavra Nasir, Heather D. Bean, Christiaan A. Rees, Edith Zemanick, Jane E. Hill. (2018) Volatile molecules from bronchoalveolar lavage fluid can “rule-in” Pseudomonas aeruginosa and “rule-out” Staphylococcus aureus infection in cystic fibrosis patients. Scientific Reports. 8, 826. Link


Lawrence A. Adutwum, A. Paulina de la Mata, Heather D. Bean, Jane E. Hill, James J. Harynuk. (2017) Estimation of start and stop numbers for cluster resolution feature selection algorithm; An empirical approach using null distribution analysis of fisher ratios. Analytical and Bioanalytical Chemistry. 409, 6699-6708. Link


Heather D. Bean*, Christiaan A. Rees*, Jane E. Hill. (2016) Comparative analysis of the volatile metabolomes of Pseudomonas aeruginosa clinical isolates. Journal of Breath Research. 10, 047102. [*co-first authors] Link

Alex Gifford, Sven Willger, Emily Dolben, Lisa Moulton, Dana Dorman, Heather D. Bean, Jane E. Hill, Thomas Hampton, Alix Ashare, Deborah A. Hogan. (2016) The use of a multiplex transcript method for the analysis of the Pseudomonas aeruginosa gene expression profiles in the cystic fibrosis lung. Infection and Immunity. 84, 2995-3006. Link


(editorial) Heather D. Bean, Joachim D. Pleil, Jane E. Hill (2015). New analytical and statistical approaches for interpreting the relationships among environmental stressors and biomarkers. Biomarkers 20, 1-4. Link

Heather D. Bean*, Theodore R. Mellors*, Jiangjiang Zhu, Jane E. Hill. (2015) Profiling aged artisanal cheddar cheese using secondary electrospray ionization-mass spectrometry (SESI-MS). Journal of Agricultural and Food Chemistry. 63, 4386-4392. [*co-first authors] Link

Heather D. Bean, Jane E. Hill, Jean-Marie D. Dimandja. (2015) Improving the quality of biomarker candidates in untargeted metabolomics via peak table-based alignment of two dimensional gas chromatography-mass spectrometry data. Journal of Chromatography A. 1394, 111-117. Link

Heather D. Bean*, Jaime Jiménez-Díaz*, Jiangjiang Zhu, Jane E. Hill. (2015) Breathprints of model murine bacterial lung infections are linked with immune response. European Respiratory Journal. 45, 181-190. [*co-first authors] Link Editorial Feature Article: European Respiratory Journal. 45, 21-24. Link


Heather D. Bean*, Jiangjiang Zhu*, Jackson C. Sengle, Jane E. Hill. (2014) Identifying methicillin-resistant Staphylococcus aureus (MRSA) lung infections in mice via breath analysis using secondary electrospray ionization-mass spectrometry (SESI-MS). Journal of Breath Research. 8, 041001. [*co-first authors] Publisher Featured Article Link


Jiangjiang Zhu, Jaime Jiménez-Díaz, Heather D. Bean, Nirav A. Dapthary, Minara I. Aliyeva, Lennart K. A. Lundblad, Jane E. Hill. (2013) Robust detection of P. aeruginosa and S. aureus acute lung infections by secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting: From initial infection to clearance. Journal of Breath Research. 7, 037106. Link

Jiangjiang Zhu, Heather D. Bean, Jaime Jiménez-Díaz, Jane E. Hill. (2013) Secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting of multiple bacterial pathogens, a mouse model study. Journal of Applied Physiology. 114, 1544-1549. Link

Jiangjiang Zhu, Heather D. Bean, Matthew J. Wargo, Laurie W. Leclair, Jane E. Hill. (2013) Detecting bacterial lung infections: In vivo evaluation of in vitro fingerprints. Journal of Breath Research. 7, 016003. Publisher Featured Article Link


Heather D. Bean, Jean-Marie D. Dimandja, Jane E. Hill. (2012) Bacterial volatile discovery using solid phase microextraction and comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry. Journal of Chromatography B. 901, 41-46. Link


Lakshmi N. Anumukonda, Avery Young, David G. Lynn, Ragan Buckley, Amena Warrayat, Christina L. Graves, Heather D. Bean, and Nicholas V. Hud. (2011) Adenine synthesis in a model prebiotic reaction: Connecting origins of life chemistry with biology. Journal of Chemical Education. 88, 1698-1701. Link

Heather D. Bean, Jiangjiang Zhu, Jane E. Hill. (2011) Characterizing bacterial volatiles using secondary electrospray ionization mass spectrometry. Journal of Visualized Experiments. 52, http://www.jove.com/details.php?id=2664.


Jiangjiang Zhu, Heather D. Bean, Yin-Ming Kuo, Jane E. Hill (2010). Fast detection of volatile organic compounds from bacterial cultures by SESI-MS. Journal of Clinical Microbiology 48, 4426-4431. Link

Irena Mamajanova, Aaron E. Engelhart, Heather D. Bean, Nicholas V. Hud (2010). DNA and RNA in anhydrous media: Evidence for duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent. Angewandte Chemie, International Edition 49, 6310-6314. Link


Heather D. Bean, David G. Lynn, Nicholas V. Hud (2009). Self-Assembly and the origin of the first RNA-like polymers, in Chemical Evolution II: From the Origins of Life to Modern Society, Zaikowski, L., Friedrich, J. M. and Seidel, S. R., Eds. Washington, DC, American Chemical Society. 1025: pp. 109-132. Link

Yinghong Sheng, Heather D. Bean, Irena Mamajanov, Nicholas V. Hud, Jerzy Leszczynski (2009). Comprehensive investigation of the energetics of pyrimidine nucleoside formation under prebiotic conditions. Journal of the American Chemical Society 131, 16088-16095. Link


Heather D. Bean, Yinghong Sheng, James P. Collins, Frank A. L. Anet, Jerzy Leszczynski, Nicholas V. Hud (2007). Formation of a β-pyrimidine nucleoside by a free pyrimidine base and ribose in a plausible prebiotic reaction. Journal of the American Chemical Society 129, 9556-9557Link


Heather D. Bean, Frank A. L. Anet, Ian R. Gould, Nicholas V. Hud (2006). Glyoxylate as a backbone linkage for a prebiotic ancestor of RNA. Origins of Life and Evolution of Biospheres 36, 39-63. Link